BioDecode Articles
A collection of guides explaining genome analysis, DNA data files, and genetic variant interpretation, including resources on ClinVar and VCF files.
Variant Not Found In ClinVar
Got no exact ClinVar match for a VCF position, rsID, or HGVS-style name? Use this non-diagnostic checklist before assuming the database or file is wrong.
Read articleRsID Vs HGVS
A practical, non-diagnostic guide to matching rsID, HGVS, CHROM:POS:REF:ALT, and ClinVar identifiers when reviewing genome file rows.
Read articleGRCh37 Vs GRCh38
Learn how GRCh37 vs GRCh38 affects variant lookup, where to find build clues, and why CHROM, POS, REF, and ALT should be checked before using ClinVar context.
Read articleVCF Columns Explained
A plain-English guide to VCF columns, using one fictional row to explain variant identity, call quality, INFO fields, and cautious ClinVar context.
Read articleFamily Genetics And Birth Defects
A careful overview of inherited patterns, family history, and why genetic counseling can help with preconception questions.
Read articleHow To Use ClinVar
ClinVar is useful for context, but careful interpretation requires checking conflicts, review status, and limits.
Read articlePathogenic Vs Likely Pathogenic Vs VUS
A clear explanation of common variant labels and why uncertainty should stay visible in any interpretation.
Read articleWhat Is ClinVar
A plain-language explanation of what ClinVar stores, what its labels mean, and where interpretation limits begin.
Read articleWhat ClinVar Can And Cannot Tell You
ClinVar can add useful context to a DNA result, but it cannot diagnose you. Here is how to read it carefully.
Read articleClinVar Stars Explained
ClinVar stars describe review depth, not disease severity. Here is how to use star levels correctly.
Read articleHow To Analyze Your Genome
A practical, cautious walkthrough for analyzing a raw DNA file and using ClinVar as a reference layer.
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