Understand your genome — privately and in minutes
Match your genome against 4.2 million ClinVar is a public database from the U.S. National Library of Medicine that explains how genetic variants may relate to health. variants — including pathogenic markers — privately on your own computer.
Supports genome files from
Supports genome files from
How It Works
Three steps. Under five minutes from download to your first report. Everything stays on your computer.
Install & Activate
Download for macOS or Windows, enter your license key, and BioDecode automatically downloads and builds the ClinVar database. One-time setup, about 60 seconds.
Drop Your Genome File
Drag your genome file into the app (VCF, TXT, CSV, TSV, GZ, or ZIP). BioDecode parses variants and automatically matches them against 4.2 million ClinVar entries — all locally.
View & Export Your Report
Your interactive report appears right in the app. Copy findings or save as PDF in one click so you can paste into ChatGPT or any LLM, or share with your doctor.
Don't Have a Genome File Yet?
BioDecode analyzes a genome file you already own. If you're not sure what you have — or don't have one yet — start here.
Already tested with 23andMe, Ancestry, Nebula, or similar?
You likely already have what you need. Most providers let you download your raw data or sequencing files from your account settings in a few minutes — no new test required.
- If it came from an ancestry-style kit
- 23andMe, Ancestry, MyHeritage and FamilyTreeDNA read a genotyping array — roughly 640,000 pre-selected positions, a fraction of 1% of your ~3 billion base pairs. BioDecode checks every one of them, but it can only see the positions your kit tested. For full coverage, consider whole genome sequencing
- If it came from whole genome sequencing
- Nebula, Dante Labs, Sequencing.com or a clinical lab already give you virtually your entire genome — nothing further to buy. Load your VCF and BioDecode reads its supported variant records locally.
Never had your DNA sequenced?
Consider 30x whole genome sequencing. It reads virtually your entire genome — millions more positions than an ancestry test kit — giving BioDecode far more of your DNA to check against ClinVar. Sequencing.com offers whole genome sequencing, including an expedited option, and lets you download your genome data files to analyze locally.
- What you get back
- Your own genome data files, covering virtually all ~3 billion base pairs rather than a pre-selected 640,000. They're yours to keep and re-run locally — ClinVar grows every month, and a file you already own can be checked against it again for free.
Affiliate disclosure: BioDecode may earn a commission if you buy through this Sequencing.com link. Sequencing.com is an independent company with its own terms and privacy policy.
Built for Privacy. Built for Science.
Every design decision prioritizes your data security and scientific accuracy.
Zero Data Transmission
Your genomic data never leaves your device. No servers, no cloud, no API calls with your genetic information. Everything runs locally.
Scientifically Curated Database
Powered by ClinVar, a curated database maintained by the U.S. National Center for Biotechnology Information (NCBI) — the gold standard for variant classification.
Whole Genome in Under a Minute
Parses 4.7M+ variants and cross-references the complete ClinVar database in under 60 seconds. No waiting for cloud servers.
Share Insights Safely
Easily copy findings or save as PDF for personal use, then paste into ChatGPT or any LLM, or share with your healthcare provider.
Comprehensive Categorization
Pathogenic and likely pathogenic findings flag known disease-linked variants. VUS means uncertain significance (not enough evidence yet). Drug response shows variants that may affect medication response, and risk factors show variants associated with increased risk. Every finding includes ClinVar star ratings and source links.
Buy Once, Own Forever
No subscriptions, no per-report fees. One-time purchase for macOS and Windows. Update the ClinVar database anytime from the free NCBI source.
Why Privacy Matters for Genomics
Your DNA is not just data — it's the most personal information that exists.
Uniquely Identifying
Even a small set of genetic variants can uniquely identify you. Unlike a password, you can never change your DNA. Once genomic data is exposed, it's exposed permanently.
Family Implications
Your genetic data reveals information about your parents, siblings, and children. Sharing your genome doesn't just affect you — it has implications for your entire family.
Health Predispositions
Genomic data can reveal predispositions to diseases, carrier status, and drug sensitivities. This information could be used against you by insurers or employers if it falls into the wrong hands.
The BioDecode Promise
BioDecode is built on privacy by design. Your genome file is processed entirely on your machine. We have no servers that receive, store, or process your genomic data. There is no account creation, no telemetry, and no network calls with your data. The application works fully offline after initial setup.
Why we chose local-first analysis
Many DNA services ask you to upload your genome to cloud servers you do not control. If those companies are acquired or policies change, your data may be exposed to new risks. BioDecode avoids that model: analysis runs locally on your computer, so your genomic data stays with you.
Read our full privacy storyGet BioDecode
One-time purchase. No subscription. No per-report fees. Your data stays yours, forever.
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You'll need a raw DNA or genome file to analyze. Don't have one yet?