BioDecode matches your whole genome sequencing variants against 4.2 million ClinVar entries — entirely on your machine. No uploads, no cloud, no compromises on privacy.
Three steps to understand your genomic variants. Everything runs on your computer — nothing is uploaded anywhere.
Download the desktop app, enter your license key, and BioDecode automatically sets up the ClinVar database on first launch. One-time setup, about 60 seconds.
Drop your VCF or VCF.GZ file into the app. BioDecode parses every variant and cross-references against 4.2 million ClinVar entries — all locally on your machine.
The full interactive report appears right in the app. Copy the Markdown to paste into any LLM for a plain-language explanation, or save as PDF.
Every design decision prioritizes your data security and scientific accuracy.
Your VCF file is processed entirely on your machine. No server, no cloud, no API calls with your genetic data. Ever.
All variant classifications come directly from NCBI ClinVar. Deterministic, citable, reproducible. No AI guesswork on clinical significance.
Export de-identified reports as Markdown. Paste into ChatGPT, Claude, or Gemini for plain-language explanations — on your terms.
Full whole-genome analysis in under 60 seconds. Parses 4.7M+ variants and matches against the complete ClinVar database locally.
Pathogenic, likely pathogenic, VUS, drug response, risk factors — all categorized with ClinVar star ratings and linked to source evidence.
No subscriptions, no per-report fees. Buy once, own it forever. Available for macOS, Windows, and Linux. Update ClinVar anytime from the free NCBI source.
One-time purchase. Download instantly. Your data stays yours.
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