23andMe
How to Analyze Your 23andMe Raw Data
What the file actually contains, how to download it, and how to check it for health-relevant variants without uploading it anywhere.
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Privacy-First
Understand your genome — privately and in minutes
Match your genome against 4.2 million ClinVar is a public database from the U.S. National Library of Medicine that explains how genetic variants may relate to health. variants — including pathogenic markers — privately on your own computer.
Supports genome files from
*BioDecode is not affiliated with these companies.
BioDecode
ClinVar database ready — 4.28M variants
Analysis Complete
8
Pathogenic
3
Likely Pathogenic
52
Drug Response
324
VUS (uncertain)
Copy Findings
Save as PDF
View Report
Supports genome files from
*BioDecode is not affiliated with these companies.
How It Works
Three steps. Under five minutes from download to your first report. Everything stays on your computer.
1
Install & Activate
Download for macOS or Windows, enter your license key, and BioDecode automatically downloads and builds the ClinVar database. One-time setup, about 60 seconds.
2
Drop Your Genome File
Drag your genome file into the app (VCF, TXT, CSV, TSV, GZ, or ZIP). BioDecode parses variants and automatically matches them against 4.2 million ClinVar entries — all locally.
3
View & Export Your Report
Your interactive report appears right in the app. Copy findings or save as PDF in one click so you can paste into ChatGPT or any LLM, or share with your doctor.
Built for Privacy. Built for Science.
Every design decision prioritizes your data security and scientific accuracy.
Zero Data Transmission
Your genomic data never leaves your device. No servers, no cloud, no API calls with your genetic information. Everything runs locally.
Scientifically Curated Database
Powered by ClinVar, a curated database maintained by the U.S. National Center for Biotechnology Information (NCBI) — the gold standard for variant classification.
Whole Genome in Under a Minute
Parses 4.7M+ variants and cross-references the complete ClinVar database in under 60 seconds. No waiting for cloud servers.
Share Insights Safely
Easily copy findings or save as PDF for personal use, then paste into ChatGPT or any LLM, or share with your healthcare provider.
Comprehensive Categorization
Pathogenic and likely pathogenic findings flag known disease-linked variants. VUS means uncertain significance (not enough evidence yet). Drug response shows variants that may affect medication response, and risk factors show variants associated with increased risk. Every finding includes ClinVar star ratings and source links.
Buy Once, Own Forever
No subscriptions, no per-report fees. One-time purchase for macOS and Windows. Update the ClinVar database anytime from the free NCBI source.
Why Privacy Matters for Genomics
Your DNA is not just data — it's the most personal information that exists.
Uniquely Identifying
Even a small set of genetic variants can uniquely identify you. Unlike a password, you can never change your DNA. Once genomic data is exposed, it's exposed permanently.
Family Implications
Your genetic data reveals information about your parents, siblings, and children. Sharing your genome doesn't just affect you — it has implications for your entire family.
Health Predispositions
Genomic data can reveal predispositions to diseases, carrier status, and drug sensitivities. This information could be used against you by insurers or employers if it falls into the wrong hands.
The BioDecode Promise
BioDecode is built on privacy by design. Your genome file is processed entirely on your machine. We have no servers that receive, store, or process your genomic data. There is no account creation, no telemetry, and no network calls with your data. The application works fully offline after initial setup.
Why we chose local-first analysis
Many DNA services ask you to upload your genome to cloud servers you do not control. If those companies are acquired or policies change, your data may be exposed to new risks. BioDecode avoids that model: analysis runs locally on your computer, so your genomic data stays with you.
Read our full privacy storyLearn before you analyze
Plain-English guides to reading your raw DNA data — and keeping it private.
Privacy
Is It Safe to Upload Your DNA?
What the law does and doesn't protect, what has already gone wrong, and why local analysis avoids the risk entirely.
Read articleClinVar
How to Find Pathogenic Variants in Your Raw DNA
What ClinVar classifications mean, how to check your file for flagged markers, and how to read a match without over-interpreting it.
Read articleGet BioDecode
One-time purchase. No subscription. No per-report fees. Your data stays yours, forever.
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